HCID 86656912, compound → HCID 86656913, compound

HRID 410999Notes

Reaction equation

HRID 410999 reaction equation
C(OC(=O)[N:7]([CH2:11][CH2:12][NH:13][C:14]([C:16]1[CH:36]=[CH:35][C:19]2[N:20]([CH3:34])[C:21]([NH:23][C:24]3[S:25][C:26]4[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:27]=4[N:28]=3)=[N:22][C:18]=2[CH:17]=1)=[O:15])[CH2:8][CH2:9][F:10])(C)(C)C>Cl.O1CCOCC1>[ClH:33].[ClH:33].[F:10][CH2:9][CH2:8][NH:7][CH2:11][CH2:12][NH:13][C:14]([C:16]1[CH:36]=[CH:35][C:19]2[N:20]([CH3:34])[C:21]([NH:23][C:24]3[S:25][C:26]4[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:27]=4[N:28]=3)=[N:22][C:18]=2[CH:17]=1)=[O:15]

Participants

4

Reactant 1

HCID 86656912HCID 86656912, compound

Product 1

HCID 86656913HCID 86656913, compoundYield 293.1%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

2-(6-Chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid [2-(2-fluoro-ethylamino)-ethyl]-amide dihydrochloride (65 mg) was prepared by following General Procedure L starting from (2-{[2-(6-chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carbonyl]-amino}-ethyl)-(2-fluoro-ethyl)-carbamic acid tert-butyl ester (70 mg) in 4M HCl in dioxane (1 mL). LC/MS: m/z 446.6.

Sources & evidence

ORD record
ord-787c57ccd3ef495490afe86931a815f3
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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