HCID 67333336, compound → Ethyl 4-amino-3-(methylamino)benzoate

HRID 411001Notes

Reaction equation

HRID 411001 reaction equation
[CH2:1]([O:3][C:4](=[O:16])[C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[C:7]([NH:14][CH3:15])[CH:6]=1)[CH3:2]>CO.[Pd]>[CH2:1]([O:3][C:4](=[O:16])[C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[C:7]([NH:14][CH3:15])[CH:6]=1)[CH3:2]

Participants

4

Reactant 1

HCID 67333336HCID 67333336, compound

Product 1

HCID 67332734Ethyl 4-amino-3-(methylamino)benzoateYield 86.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

4-Amino-3-methylamino-benzoic acid ethyl ester (2.1 g) was prepared by following General Procedure B starting from 3-methylamino-4-nitro-benzoic acid ethyl ester (2.8 g) and Pd—C (560 mg) in methanol (25 mL).

Sources & evidence

ORD record
ord-b5f84632771345e9a671e85022634d48
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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