Hydrochloric Acid → 1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid pyrrolidin-3-ylamide dihydrochloride

HRID 411011Notes

Reaction equation

HRID 411011 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([NH:13][C:14]([C:16]2[CH:40]=[CH:39][C:19]3[N:20]([CH3:38])[C:21]([NH:23][C:24]4[S:25][C:26]5[CH:32]=[C:31]([O:33][C:34]([F:37])([F:36])[F:35])[CH:30]=[CH:29][C:27]=5[N:28]=4)=[N:22][C:18]=3[CH:17]=2)=[O:15])[CH2:9]1)=O)(C)(C)C.[ClH:41]>O1CCOCC1>[ClH:41].[ClH:41].[NH:8]1[CH2:12][CH2:11][CH:10]([NH:13][C:14]([C:16]2[CH:40]=[CH:39][C:19]3[N:20]([CH3:38])[C:21]([NH:23][C:24]4[S:25][C:26]5[CH:32]=[C:31]([O:33][C:34]([F:35])([F:36])[F:37])[CH:30]=[CH:29][C:27]=5[N:28]=4)=[N:22][C:18]=3[CH:17]=2)=[O:15])[CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 866569263-{[1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5 carbonyl]-amino}-pyrrolidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 866569271-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid pyrrolidin-3-ylamide dihydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid pyrrolidin-3-ylamide dihydrochloride (330 mg) was prepared by following General Procedure L starting from 3-{[1-methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5 carbonyl]-amino}-pyrrolidine-1-carboxylic acid tert-butyl ester (400 mg) in 4M HCl in dioxane (2 mL).

Sources & evidence

ORD record
ord-395e2c72fcec4793a6c2df0bbb2897db
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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