HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → (R)-1-((R)-3-Amino-pyrrolidin-1-yl)-propan-2-ol dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | [(R)-1-((R)-2-Hydroxy-propyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester | HCID 67331578 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (R)-1-((R)-3-Amino-pyrrolidin-1-yl)-propan-2-ol dihydrochloride | HCID 67334534 | — |
Reaction Steps
(R)-1-((R)-3-Amino-pyrrolidin-1-yl)-propan-2-ol dihydrochloride (140 mg) was prepared by following General Procedure L starting from [(R)-1-((R)-2-hydroxy-propyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester (244 mg) and DCM (2 mL) in 4M HCl in dioxane (2 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759535B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-482f71f4e97d4f198dba6df2445a7e1d |
| Source note | uspto-grants-2014_06 |