Dichloromethane → (R)-1-((R)-3-Amino-pyrrolidin-1-yl)-propan-2-ol dihydrochloride

HRID 411016Notes

Reaction equation

HRID 411016 reaction equation
C(OC(=O)[NH:7][C@@H:8]1[CH2:12][CH2:11][N:10]([CH2:13][C@H:14]([OH:16])[CH3:15])[CH2:9]1)(C)(C)C.C(Cl)[Cl:19]>Cl.O1CCOCC1>[ClH:19].[ClH:19].[NH2:7][C@@H:8]1[CH2:12][CH2:11][N:10]([CH2:13][C@H:14]([OH:16])[CH3:15])[CH2:9]1

Participants

5

Reactant 2

HCID 6344DichloromethaneHCID 67331578[(R)-1-((R)-2-Hydroxy-propyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester

Product 1

HCID 67334534(R)-1-((R)-3-Amino-pyrrolidin-1-yl)-propan-2-ol dihydrochloride

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

(R)-1-((R)-3-Amino-pyrrolidin-1-yl)-propan-2-ol dihydrochloride (140 mg) was prepared by following General Procedure L starting from [(R)-1-((R)-2-hydroxy-propyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester (244 mg) and DCM (2 mL) in 4M HCl in dioxane (2 mL).

Sources & evidence

ORD record
ord-482f71f4e97d4f198dba6df2445a7e1d
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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