HCID 86656933, compound → HCID 86656936, compound

HRID 411020Notes

Reaction equation

HRID 411020 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][N:10]1[CH2:14][CH2:13][CH:12]([NH:15][C:16]([C:18]2[CH:38]=[CH:37][C:21]3[N:22]([CH3:36])[C:23]([NH:25][C:26]4[S:27][C:28]5[CH:34]=[C:33]([Cl:35])[CH:32]=[CH:31][C:29]=5[N:30]=4)=[N:24][C:20]=3[CH:19]=2)=[O:17])[CH2:11]1)(C)(C)C>Cl.O1CCOCC1>[ClH:35].[ClH:35].[ClH:35].[NH2:7][CH2:8][CH2:9][N:10]1[CH2:14][CH2:13][CH:12]([NH:15][C:16]([C:18]2[CH:38]=[CH:37][C:21]3[N:22]([CH3:36])[C:23]([NH:25][C:26]4[S:27][C:28]5[CH:34]=[C:33]([Cl:35])[CH:32]=[CH:31][C:29]=5[N:30]=4)=[N:24][C:20]=3[CH:19]=2)=[O:17])[CH2:11]1

Participants

4

Reactant 1

HCID 86656933HCID 86656933, compound

Product 1

HCID 86656936HCID 86656936, compoundYield 323.3%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

2-(6-Chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid [1-(2-amino-ethyl)-pyrrolidin-3-yl]amide trihydrochloride (46 mg) was prepared by following General Procedure L starting from [2-(3-{[2-(6-chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carbonyl]-amino}-pyrrolidin-1-yl)-ethyl]-carbamic acid tert-butyl ester (56 mg) in 4M HCl in dioxane (1 mL).

Sources & evidence

ORD record
ord-b429f71d818b4ee1b677201a2aa60241
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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