HCID 86656953, compound → HCID 86656954, compound

HRID 411032Notes

Reaction equation

HRID 411032 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([C:17]2[CH:37]=[CH:36][C:20]3[N:21]([CH3:35])[C:22]([NH:24][C:25]4[S:26][C:27]5[CH:33]=[C:32]([Cl:34])[CH:31]=[CH:30][C:28]=5[N:29]=4)=[N:23][C:19]=3[CH:18]=2)=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[ClH:34].[ClH:34].[NH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([C:17]2[CH:37]=[CH:36][C:20]3[N:21]([CH3:35])[C:22]([NH:24][C:25]4[S:26][C:27]5[CH:33]=[C:32]([Cl:34])[CH:31]=[CH:30][C:28]=5[N:29]=4)=[N:23][C:19]=3[CH:18]=2)=[O:16])[CH2:10][CH2:9]1

Participants

4

Reactant 1

HCID 86656953HCID 86656953, compound

Product 1

HCID 86656954HCID 86656954, compoundYield 296.1%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

2-(6-Chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid piperidin-4-ylamide dihydrochloride (750 mg) was prepared by following General Procedure L starting from 4-{[2-(6-chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester (800 mg) in 4M HCl in dioxane (5 mL).

Sources & evidence

ORD record
ord-6d382a55c9df45bfb1f2043680cbf475
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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