Hydrochloric Acid → 2-(6-Chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid (2-amino-ethyl)-amide dihydrochloride

HRID 411043Notes

Reaction equation

C(OC(=O)[NH:7][CH2:8][CH2:9][NH:10][C:11]([C:13]1[CH:33]=[CH:32][C:16]2[N:17]([CH3:31])[C:18]([NH:20][C:21]3[S:22][C:23]4[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:24]=4[N:25]=3)=[N:19][C:15]=2[CH:14]=1)=[O:12])(C)(C)C.[ClH:35]>>[ClH:30].[ClH:35].[NH2:7][CH2:8][CH2:9][NH:10][C:11]([C:13]1[CH:33]=[CH:32][C:16]2[N:17]([CH3:31])[C:18]([NH:20][C:21]3[S:22][C:23]4[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:24]=4[N:25]=3)=[N:19][C:15]=2[CH:14]=1)=[O:12]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 86656963(2-{[2-(6-Chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carbonyl]-amino}-ethyl)-carbamic acid tert-butyl ester

Product 1

HCID 866569642-(6-Chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid (2-amino-ethyl)-amide dihydrochloride

Procedure

2-(6-Chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid (2-amino-ethyl)-amide dihydrochloride (225 mg) was prepared by following General Procedure L using (2-{[2-(6-chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carbonyl]amino}-ethyl)-carbamic acid tert-butyl ester (250 mg) and hydrogen chloride (1.25 mL, 4.0 M solution in 1,4-dioxane).

Sources & evidence

ORD record: ord-705097c3bbfb4669870cbab7c4226726
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08759535B2

Reaction notes

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