HCID 86656967, compound → HCID 86656968, compound

HRID 411046Notes

Reaction equation

C[O:2][CH:3](OC)[CH2:4][NH:5][C:6]([C:8]1[CH:28]=[CH:27][C:11]2[N:12]([CH3:26])[C:13]([NH:15][C:16]3[S:17][C:18]4[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:19]=4[N:20]=3)=[N:14][C:10]=2[CH:9]=1)=[O:7]>Cl.O1CCOCC1>[O:2]=[CH:3][CH2:4][NH:5][C:6]([C:8]1[CH:28]=[CH:27][C:11]2[N:12]([CH3:26])[C:13]([NH:15][C:16]3[S:17][C:18]4[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:19]=4[N:20]=3)=[N:14][C:10]=2[CH:9]=1)=[O:7]

Participants

Conditions

Temperature: 50 °C

Procedure

2-(6-Chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid (2-oxo-ethyl)-amide (574 mg) was prepared starting from 2-(6-chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid (2,2-dimethoxy-ethyl)-amide (700 mg) in 4M HCl-dioxane (3 mL). The reaction was heated to 50° C. for 5 h. The solvent was evaporated to give crude product.

Workup

customThe solvent was evaporated
customto give crude product

Sources & evidence

ORD record: ord-863b38c3e576448e976917517adddde6
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08759535B2

Reaction notes

Loading…