HCID 86656974, compound → HCID 86656975, compound

HRID 411062Notes

Reaction equation

HRID 411062 reaction equation
C(O[C:6](=O)[N:7]([CH2:9][CH2:10][N:11]1[C:15]2[CH:16]=[CH:17][C:18]([C:20](=[O:28])[NH:21][CH2:22][C:23](=[O:27])[N:24]([CH3:26])[CH3:25])=[CH:19][C:14]=2[N:13]=[C:12]1[NH:29][C:30]1[S:31][C:32]2[CH:38]=[C:37]([Cl:39])[CH:36]=[CH:35][C:33]=2[N:34]=1)C)(C)(C)C>Cl.O1CCOCC1>[ClH:39].[ClH:39].[CH3:26][N:24]([CH3:25])[C:23]([CH2:22][NH:21][C:20]([C:18]1[CH:17]=[CH:16][C:15]2[N:11]([CH2:10][CH2:9][NH:7][CH3:6])[C:12]([NH:29][C:30]3[S:31][C:32]4[CH:38]=[C:37]([Cl:39])[CH:36]=[CH:35][C:33]=4[N:34]=3)=[N:13][C:14]=2[CH:19]=1)=[O:28])=[O:27]

Participants

4

Reactant 1

HCID 86656974HCID 86656974, compound

Product 1

HCID 86656975HCID 86656975, compoundYield 269.7%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

2-(6-Chloro-benzothiazol-2-ylamino)-1-(2-methylamino-ethyl)-1H-benzoimidazole-5-carboxylic acid dimethylcarbamoylmethyl-amide dihydrochloride (60 mg) was prepared by following General Procedure L starting from {2-[2-(6-chloro-benzothiazol-2-ylamino)-5-(dimethylcarbamoylmethyl-carbamoyl)-benzoimidazol-1-yl]-ethyl}-methyl-carbamic acid tert-butyl ester (70 mg) in 4M HCl in dioxane (1 mL). LC/MS: m/z 485.5.

Sources & evidence

ORD record
ord-31afffadf2c847e3a7640cee6e4ec4cd
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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