HRID411069

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CN(C)C(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)CNC(=O)c1ccc2c(c1)nc(Nc1nc3ccc(C(F)(F)F)cc3s1)n2C

HCID86656982

未命名化合物

PRODUCTS

生成物

结构：CN(C)C(=O)[C@H](CCCCN)NC(=O)CNC(=O)c1ccc2c(c1)nc(Nc1nc3ccc(C(F)(F)F)cc3s1)n2C.Cl.Cl

HCID86656983

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

1-Methyl-2-(6-trifluoromethyl-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid [((S)-5-amino-1-dimethylcarbamoyl-pentylcarbamoyl)-methyl]-amide dihydrochloride (150 mg) was prepared by following General Procedure L starting from [((S)-5-dimethylcarbamoyl-5-(2-{[1-methyl-2-(6-trifluoromethyl-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carbonyl]-amino}-acetylamino)-pentyl]-carbamic acid tert-butyl ester (200 mg) in 4M HCl in dioxane (1 mL) and DCM (2 mL). LC/MS: m/z 547.8.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-571f2b5874034f8bbd71a5f5d382b10f
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08759535B2
来源说明: uspto-grants-2014_06

反应 SMILES

C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][C@@H:12]([C:44](=[O:48])[N:45]([CH3:47])[CH3:46])[NH:13][C:14](=[O:43])[CH2:15][NH:16][C:17]([C:19]1[CH:42]=[CH:41][C:22]2[N:23]([CH3:40])[C:24]([NH:26][C:27]3[S:28][C:29]4[CH:35]=[C:34]([C:36]([F:39])([F:38])[F:37])[CH:33]=[CH:32][C:30]=4[N:31]=3)=[N:25][C:21]=2[CH:20]=1)=[O:18])(C)(C)C.[ClH:50]>O1CCOCC1.C(Cl)Cl>[ClH:50].[ClH:50].[NH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C@H:12]([NH:13][C:14]([CH2:15][NH:16][C:17]([C:19]1[CH:42]=[CH:41][C:22]2[N:23]([CH3:40])[C:24]([NH:26][C:27]3[S:28][C:29]4[CH:35]=[C:34]([C:36]([F:38])([F:39])[F:37])[CH:33]=[CH:32][C:30]=4[N:31]=3)=[N:25][C:21]=2[CH:20]=1)=[O:18])=[O:43])[C:44](=[O:48])[N:45]([CH3:46])[CH3:47]