Lithium Hydroxide → HCID 86656989, compound

HRID 411074Notes

Reaction equation

C[O:2][C:3]([C@@H:5]1[CH2:9][CH2:8][CH2:7][N:6]1[C:10](=[O:36])[CH2:11][NH:12][C:13]([C:15]1[CH:35]=[CH:34][C:18]2[N:19]([CH3:33])[C:20]([NH:22][C:23]3[S:24][C:25]4[CH:31]=[C:30]([Cl:32])[CH:29]=[CH:28][C:26]=4[N:27]=3)=[N:21][C:17]=2[CH:16]=1)=[O:14])=[O:4].[OH-].[Li+]>>[Cl:32][C:30]1[CH:29]=[CH:28][C:26]2[N:27]=[C:23]([NH:22][C:20]3[N:19]([CH3:33])[C:18]4[CH:34]=[CH:35][C:15]([C:13]([NH:12][CH2:11][C:10]([N:6]5[CH2:7][CH2:8][CH2:9][C@H:5]5[C:3]([OH:4])=[O:2])=[O:36])=[O:14])=[CH:16][C:17]=4[N:21]=3)[S:24][C:25]=2[CH:31]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 86656988HCID 86656988, compound

Product 1

HCID 86656989HCID 86656989, compoundYield 61.6%

Procedure

(S)-1-(2-{[2-(6-Chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carbonyl]-amino}-acetyl)-pyrrolidine-2-carboxylic acid (54 mg) was prepared by following General Procedure E starting from (S)-1-(2-{[2-(6-chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carbonyl]-amino}-acetyl)-pyrrolidine-2-carboxylic acid methyl ester (90 mg) and lithium hydroxide (29 mg).

Sources & evidence

ORD record: ord-e57be275885e4f8f836d13583114ab43
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08759535B2

Reaction notes

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