Lithium Hydroxide → HCID 86656986, compound

HRID 411079Notes

Reaction equation

C[O:2][C:3](=[O:29])[CH2:4][NH:5][C:6]([C:8]1[CH:28]=[CH:27][C:11]2[N:12]([CH3:26])[C:13]([NH:15][C:16]3[S:17][C:18]4[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:19]=4[N:20]=3)=[N:14][C:10]=2[CH:9]=1)=[O:7].[OH-].[Li+]>>[Cl:25][C:23]1[CH:22]=[CH:21][C:19]2[N:20]=[C:16]([NH:15][C:13]3[N:12]([CH3:26])[C:11]4[CH:27]=[CH:28][C:8]([C:6]([NH:5][CH2:4][C:3]([OH:29])=[O:2])=[O:7])=[CH:9][C:10]=4[N:14]=3)[S:17][C:18]=2[CH:24]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 86656994HCID 86656994, compound

Product 1

HCID 86656986HCID 86656986, compoundYield 62.9%

Procedure

{[2-(6-Chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carbonyl]-amino}-acetic acid (300 mg) was prepared by following General Procedure E starting from {[2-(6-chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carbonyl]-amino}-acetic acid methyl ester (493 mg) and lithium hydroxide (192 mg).

Sources & evidence

ORD record: ord-badb58c90a5d4cfc80e7e0c5ecb148c6
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08759535B2

Reaction notes

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