Lithium Hydroxide → HCID 86656998, compound

HRID 411085Notes

Reaction equation

C[O:2][C:3](=[O:32])[CH2:4][NH:5][C:6]([C:8]1[CH:31]=[CH:30][C:11]2[N:12]([CH3:29])[C:13]([NH:15][C:16]3[S:17][C:18]4[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[CH:21][C:19]=4[N:20]=3)=[N:14][C:10]=2[CH:9]=1)=[O:7].[OH-].[Li+]>>[CH3:29][N:12]1[C:11]2[CH:30]=[CH:31][C:8]([C:6]([NH:5][CH2:4][C:3]([OH:32])=[O:2])=[O:7])=[CH:9][C:10]=2[N:14]=[C:13]1[NH:15][C:16]1[S:17][C:18]2[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[CH:21][C:19]=2[N:20]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 86656999{[1-Methyl-2-(6-trifluoromethyl-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carbonyl]-amino}-acetic acid methyl ester

Product 1

HCID 86656998HCID 86656998, compoundYield 87%

Procedure

{[1-Methyl-2-(6-trifluoromethyl-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carbonyl]-amino}-acetic acid (4.22 g) was prepared by following General Procedure E starting from {[1-methyl-2-(6-trifluoromethyl-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carbonyl]-amino}-acetic acid methyl ester (5.0 g) and lithium hydroxide (1.81 g).

Sources & evidence

ORD record: ord-0208333389c54d3c9fd16457bb077723
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08759535B2

Reaction notes

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