Methanol → HCID 1477336, compound

HRID 411214Notes

Reaction equation

HRID 411214 reaction equation
COC([C:5]1([NH2:10])[CH2:9][CH:8]=[CH:7][S:6]1)=O.C(N(CC)CC)C.[CH3:18][S:19](Cl)(=[O:21])=[O:20].[CH3:23][O-:24].[Na+].[CH3:26][OH:27]>C(Cl)Cl>[CH3:18][S:19]([NH:10][C:5]1[S:6][CH:7]=[CH:8][C:9]=1[C:23]([O:27][CH3:26])=[O:24])(=[O:21])=[O:20]

Participants

7

Reactant 5

HCID 887Methanol3×HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 10942334Sodium MethoxideHCID 68732898HCID 68732898, compound

Product 1

HCID 1477336HCID 1477336, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirring solution of methyl-2-aminothiophene carboxylate (10 g) in CH2Cl2 (350 ml) at 0° C. is added triethylamine (13.51 g). Methanesulfonyl chloride (15.28 g) is then added dropwise at 0° C. over 15 min. The mixture is stirred for 16 h allowing the solution to warm to ambient temperature. The organic layer is washed with water (100 ml) and dried over MgSO4. The solvent is removed in vacuo to afford a crude residue. This material is dissolved in MeOH (400 ml) and a solution of NaOMe in methanol is added (2.92 g Na metal in 150 ml MeOH) at ambient temperature. The resulting heterogeneous mixture is stirred at ambient temperature overnight. The mixture is concentrated to approximately 150 mL volume, cooled to 0° C., and filtered to afford 14.5 g (88%) of the title compound as a tan solid (Na salt). Physical characteristics: 1H NMR (DMSO-d6) δ 2.68, 3.61, 6.23, 6.91; IR (diffuse reflectance) 1683, 1507, 1464, 1316, 1248, 1233, 1222, 1190, 1150, 1124, 1075, 979, 787, 763, 685 cm−1; MS (CI) m/z 258 (MH+).

Workup

  1. washThe organic layer is washed with water (100 ml)
  2. dry with materialdried over MgSO4
  3. customThe solvent is removed in vacuo
  4. customto afford a crude residue
  5. stirringThe resulting heterogeneous mixture is stirred at ambient temperature overnight
  6. concentrationThe mixture is concentrated to approximately 150 mL volume
  7. temperaturecooled to 0° C.
  8. filtrationfiltered

Sources & evidence

ORD record
ord-02268229095348bd8156bf9bffb5be71
Source dataset
uspto-grants-2003_05
Patent number
US06559145B2

Reaction notes

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