Sulfuric Acid → HCID 18540687, compound

HRID 411589Notes

Reaction equation

HRID 411589 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:9][C:8]=2[Cl:19])[N:5]=[C:4]([CH2:20][CH3:21])[C:3]=1[C:22]#[N:23].[OH:24]S(O)(=O)=O>>[NH2:1][C:2]1[N:6]([C:7]2[C:8]([Cl:19])=[CH:9][C:10]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:11][C:12]=2[Cl:13])[N:5]=[C:4]([CH2:20][CH3:21])[C:3]=1[C:22]([NH2:23])=[O:24]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 18540599HCID 18540599, compound

Product 1

HCID 18540687HCID 18540687, compoundYield 73%

Procedure

Part C: A solution of 1.64 g (4.64 mmol) of 5-amino-4-cyano-3-ethyl-1-(2,6-dichloro-4-carboethoxyphenyl)-pyrazole in 8 mL conc. H2SO4 was stirred at room temperature for 4 hours. The reaction was quenched carefully with ice and diluted with water. The solid was collected by suction filtration, washed with water and dried to give 1.26 g (73%) of 5-amino-3-ethyl-1-(2,6-dichloro-4-carboethoxyphenyl)pyrazole-4-carboxamide, mp 194-196° C. Mass Spec.: (CI+) 371 (M+).

Workup

  1. customThe reaction was quenched carefully with ice
  2. additiondiluted with water
  3. filtrationThe solid was collected by suction filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-1f31fc86899747fbb2a45f8c1c5a9fe3
Source dataset
uspto-grants-2003_05
Patent number
US06559152B2

Reaction notes

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