反应详情

100 mg of pyridine-3-sulfonyl chloride was added to 191 mg of 2-[[[3-methyl-4-(3-methoxypropoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole sodium salt in a mixture of 0.15 ml of triethylamine and 10 ml of dichloromethane. The reaction mixture was stirred at room temperature overnight. Dichloromethane (20 ml) was added and washed with water, and 0.1M sodium bicarbonate solution. Organic layer was dried over anhydrous magnesium sulfate and evaporated. Residue was dissolved in minimum amounts of acetonitrile and ethyl ether was added for precipitation. Solids was collected and dried to give 127 mg of the titled product.

1. washwashed with water, and 0.1M sodium bicarbonate solution
2. dry with materialOrganic layer was dried over anhydrous magnesium sulfate
3. customevaporated
4. dissolutionResidue was dissolved in minimum amounts of acetonitrile and ethyl ether
5. additionwas added for precipitation
6. customSolids was collected
7. customdried