Sodium Cyanide → HCID 69556834, compound

HRID 411624Notes

Reaction equation

HRID 411624 reaction equation
[CH:1](=[O:10])[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1.[S:11]([CH2:21][N+:22]#[C-:23])([C:14]1[CH:20]=[CH:19][C:17](C)=[CH:16][CH:15]=1)(=[O:13])=[O:12].[C-:24]#N.[Na+]>>[CH3:9][O:8][C:5]1[CH:6]=[CH:7][C:2]([C@H:1]2[O:10][CH:23]=[N:22][C@@H:21]2[S:11]([C:14]2[C:15]([CH3:24])=[CH:16][CH:17]=[CH:19][CH:20]=2)(=[O:12])=[O:13])=[CH:3][CH:4]=1

Participants

4

Reactant 3

HCID 8929Sodium CyanideHCID 312444-MethoxybenzaldehydeHCID 161915Tosylmethyl isocyanide

Product 1

HCID 69556834HCID 69556834, compound

Procedure

In a manner analogous to Preparation 1, p-anisaldehyde (0.49 mL, 4.03 mmol), tosylmethylisocyanide (0.75 g, 3.84 mmol) and NaCN (0.02 g, 0.40 mmol) gave the desired compound as a tan solid. MS(ES+) m/z 662.9 (2M+H+).

Sources & evidence

ORD record
ord-a4186c5487a74e22b74145f585d92cf6
Source dataset
uspto-grants-2003_05
Patent number
US06559172B1

Reaction notes

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