HCID 178418806, compound → 3-[(1H-pyrazol-5-ylamino)methylidene]-1H-indol-2-one

HRID 411665Notes

Reaction equation

HRID 411665 reaction equation
O/[CH:2]=[C:3]1\[C:4](=[O:12])[NH:5][C:6]2[C:11]\1=[CH:10][CH:9]=[CH:8][CH:7]=2.[NH2:13][C:14]1[CH:18]=[CH:17][NH:16][N:15]=1>O1CCCC1>[NH:16]1[CH:17]=[CH:18][C:14]([NH:13][CH:2]=[C:3]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[NH:5][C:4]2=[O:12])=[N:15]1

Participants

4

Reactant 2

HCID 178418806HCID 178418806, compoundHCID 178517101HCID 178517101, compound

Product 1

HCID 1785170953-[(1H-pyrazol-5-ylamino)methylidene]-1H-indol-2-one

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.10 g) is reacted with 0.1756 gms of 3-aminopyrazole by refluxing in tetrahydrofuran (2.7 mL) for 48 hours to yield 0.11 gms of the named compound as a solid following concentration in vacuo, dilution with isopropanol and filtration.

Workup

  1. customto yield
  2. concentration0.11 gms of the named compound as a solid following concentration in vacuo, dilution
  3. filtrationwith isopropanol and filtration

Sources & evidence

ORD record
ord-a77f6596fbc74accae9260b28c164903
Source dataset
uspto-grants-2003_05
Patent number
US06559173B1

Reaction notes

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