3-(furan-2-yl)-1H-pyrazol-5-amine → 3-[[[5-(furan-2-yl)-1H-pyrazol-3-yl]amino]methylidene]-1H-indol-2-one

HRID 411666Notes

Reaction equation

HRID 411666 reaction equation
NC1C=CNN=1.O/[CH:8]=[C:9]1\[C:10](=[O:18])[NH:11][C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2.[NH2:19][C:20]1[CH:24]=[C:23]([C:25]2[O:26][CH:27]=[CH:28][CH:29]=2)[NH:22][N:21]=1>O1CCCC1>[O:26]1[CH:27]=[CH:28][CH:29]=[C:25]1[C:23]1[NH:22][N:21]=[C:20]([NH:19][CH:8]=[C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][C:10]2=[O:18])[CH:24]=1

Participants

5

Reactant 3

HCID 5231833-(furan-2-yl)-1H-pyrazol-5-amineHCID 178418806HCID 178418806, compoundHCID 178517101HCID 178517101, compound

Product 1

HCID 1785170703-[[[5-(furan-2-yl)-1H-pyrazol-3-yl]amino]methylidene]-1H-indol-2-one

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting 3-amino-5-(2-furyl)-pyrazole for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.10 gms.) is reacted with 0.1480 gms. of 3-amino-5-(2-furyl)-pyrazole by refluxing in tetrahydrofuran (2.5 mL).

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-456798f772df4976bbdf62af34b2807d
Source dataset
uspto-grants-2003_05
Patent number
US06559173B1

Reaction notes

Loading…