HCID 178418806, 화합물 → 4-methyl-3-[(1H-pyrazol-5-ylamino)methylidene]-1H-indol-2-one

HRID 411669노트

반응식

HRID 411669 반응식
O/[CH:2]=[C:3]1\[C:4](=[O:13])[NH:5][C:6]2[C:11]\1=[C:10]([CH3:12])[CH:9]=[CH:8][CH:7]=2.O/C=C1\C(=O)NC2C\1=CC=CC=2.[NH2:26][C:27]1[CH:31]=[CH:30][NH:29][N:28]=1>O1CCCC1>[CH3:12][C:10]1[CH:9]=[CH:8][CH:7]=[C:6]2[C:11]=1[C:3](=[CH:2][NH:26][C:27]1[CH:31]=[CH:30][NH:29][N:28]=1)[C:4](=[O:13])[NH:5]2

참가 물질

5

반응물 3

HCID 178418806HCID 178418806, 화합물HCID 178423596HCID 178423596, 화합물2회HCID 178517101HCID 178517101, 화합물

생성물 1

HCID 1784235944-methyl-3-[(1H-pyrazol-5-ylamino)methylidene]-1H-indol-2-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The named compound is prepared by substituting E & Z-3-[(hydroxy)-methylene]-4-methyl-1,3-dihydro-indol-2-one for E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-4-methyl-1,3-dihydro-indol-2-one (0.110 gms.) is reacted with 0.18 mL of 3-aminopyrazole by refluxing in tetrahydrofuran (2.5 mL).

후처리

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

출처 및 근거

ORD 기록
ord-d73dafc4d154434296b12da3bbbbf17d
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06559173B1

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