3-(furan-2-yl)-1H-pyrazol-5-amine → HCID 178423593, compound

HRID 411670Notes

Reaction equation

HRID 411670 reaction equation
O/[CH:2]=[C:3]1\[C:4](=[O:13])[NH:5][C:6]2[C:11]\1=[C:10]([CH3:12])[CH:9]=[CH:8][CH:7]=2.O/C=C1\C(=O)NC2C\1=CC=CC=2.NC1C=CNN=1.[NH2:32][C:33]1[CH:37]=[C:36]([C:38]2[O:39][CH:40]=[CH:41][CH:42]=2)[NH:35][N:34]=1>O1CCCC1>[O:39]1[CH:40]=[CH:41][CH:42]=[C:38]1[C:36]1[NH:35][N:34]=[C:33]([NH:32][CH:2]=[C:3]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][C:10]=3[CH3:12])[NH:5][C:4]2=[O:13])[CH:37]=1

Participants

6

Reactant 4

HCID 5231833-(furan-2-yl)-1H-pyrazol-5-amineHCID 178418806HCID 178418806, compoundHCID 178423596HCID 178423596, compound2×HCID 178517101HCID 178517101, compound

Product 1

HCID 178423593HCID 178423593, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting E & Z-3-[(hydroxy)-methylene]-4-methyl-1,3-dihydro-indol-2-one for E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one and substituting 3-amino-5-(2-furyl)-pyrazole for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-4-methyl-1,3-dihydro-indol-2-one (0.110 gms.) is reacted with 0.2065 gms. of 3-amino-5-(2-furyl)-pyrazole by refluxing in tetrahydrofuran (2.5 mL).

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-11136934cdfc482fa126e674a1f4e258
Source dataset
uspto-grants-2003_05
Patent number
US06559173B1

Reaction notes

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