HCID 178418806, compound → HCID 178517163, compound

HRID 411672Notes

Reaction equation

HRID 411672 reaction equation
O/[CH:2]=[C:3]1\[C:4](=[O:13])[NH:5][C:6]2[C:11]\1=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=2.O/C=C1\C(=O)NC2C\1=CC=CC=2.[NH2:26][C:27]1[CH:31]=[CH:30][NH:29][N:28]=1>O1CCCC1>[Cl:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[NH:5][C:4](=[O:13])[C:3]2=[CH:2][NH:26][C:27]1[CH:31]=[CH:30][NH:29][N:28]=1

Participants

5

Reactant 3

HCID 178418806HCID 178418806, compoundHCID 178517101HCID 178517101, compoundHCID 178517165HCID 178517165, compound2×

Product 1

HCID 178517163HCID 178517163, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting E & Z-3-[(hydroxy)-methylene]-5-chloro-1,3-dihydro-indol-2-one for E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-5-chloro-1,3-dihydro-indol-2-one is reacted with 0.300 gms 3-aminopyrazole by refluxing in tetrahydrofuran.

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-b783e2d6590c42a6b946398c38d67791
Source dataset
uspto-grants-2003_05
Patent number
US06559173B1

Reaction notes

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