HCID 178418806, compound → HCID 178517099, compound

HRID 411682Notes

Reaction equation

HRID 411682 reaction equation
NC1C=CNN=1.O/[CH:8]=[C:9]1\[C:10](=[O:18])[NH:11][C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2.[NH2:19][C:20]1[C:24]([C:25]([OH:27])=[O:26])=[CH:23][NH:22][N:21]=1>O1CCCC1>[O:18]=[C:10]1[C:9](=[CH:8][NH:19][C:20]2[C:24]([C:25]([OH:27])=[O:26])=[CH:23][NH:22][N:21]=2)[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11]1

Participants

5

Reactant 3

HCID 178418806HCID 178418806, compoundHCID 178509273HCID 178509273, compoundHCID 178517101HCID 178517101, compound

Product 1

HCID 178517099HCID 178517099, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting 3-amino-1H-pyrazole-4-carboxylic acid for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.100 gms.) is reacted with 0.1601 gms. of 3-amino-1H-pyrazole-4-carboxylic acid by refluxing in tetrahydrofuran (2.5 mL).

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-39130590f4fd48c18ce14aaa97b064f1
Source dataset
uspto-grants-2003_05
Patent number
US06559173B1

Reaction notes

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