HCID 178418806, compound → HCID 178517098, compound

HRID 411684Notes

Reaction equation

HRID 411684 reaction equation
NC1C=CNN=1.O/[CH:8]=[C:9]1\[C:10](=[O:18])[NH:11][C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2.[Br:19][C:20]1[C:21]([NH2:25])=[N:22][NH:23][CH:24]=1>O1CCCC1>[Br:19][C:20]1[C:21]([NH:25][CH:8]=[C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][C:10]2=[O:18])=[N:22][NH:23][CH:24]=1

Participants

5

Reactant 3

HCID 178418806HCID 178418806, compoundHCID 178509245HCID 178509245, compoundHCID 178517101HCID 178517101, compound

Product 1

HCID 178517098HCID 178517098, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting 4-bromo-1H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.100 gms.) is reacted with 0.2141 gms. of 4-bromo-1H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (2.5 mL).

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-bcfbd27b16304bd7b8bee1e1887043f0
Source dataset
uspto-grants-2003_05
Patent number
US06559173B1

Reaction notes

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