HCID 178418806, compound → HCID 178423809, compound

HRID 411700Notes

Reaction equation

HRID 411700 reaction equation
NC1C=CNN=1.O/[CH:8]=[C:9]1\[C:10](=[O:18])[NH:11][C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2.[CH3:19][C:20]1[CH:25]=[C:24]([CH3:26])[CH:23]=[CH:22][C:21]=1[C:27]1[CH:28]=[C:29]([NH2:32])[NH:30][N:31]=1>O1CCCC1>[CH3:19][C:20]1[CH:25]=[C:24]([CH3:26])[CH:23]=[CH:22][C:21]=1[C:27]1[CH:28]=[C:29]([NH:32][CH:8]=[C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][C:10]2=[O:18])[NH:30][N:31]=1

Participants

5

Reactant 3

HCID 178418806HCID 178418806, compoundHCID 178423838HCID 178423838, compoundHCID 178517101HCID 178517101, compound

Product 1

HCID 178423809HCID 178423809, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting 5-(2,4-dimethyl-phenyl)-2H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.100 gms.) is reacted with 0.250 gms. 5-(2,4-dimethyl-phenyl)-2H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (2.0 mL) over the weekend.

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-05444b835c1d48a78104b6b225b507fd
Source dataset
uspto-grants-2003_05
Patent number
US06559173B1

Reaction notes

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