反应详情

Heteroaryl derivatives to replace 1,3-dihydro-2H-isoindole-1-carboxylate may be prepared as outlined in Scheme 2. 4-Hydroxy-(L)-proline derivative D is oxidized to 4-keto-(L)-proline E which is formylated and then treated with an appropriate hydrazine derivative to form pyrrolidinyl-pyrazole F. The ester in F is hydrolyzed and reacted with amino acid C followed by protecting group removal to form G. The pyrrolidine-amine in G is sulfonylated and the ester removed to form the desired product H.

1. custommay be prepared