Hydrazine → HCID 178420599, Verbindung

HRID 411741Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 411741
[CH:1]1(C([O-])=O)[C:9]2[C:4](=CC=CC=2)[CH2:3][NH:2]1.O[CH:14]1C[NH:17][C@H:16](C(O)=O)[CH2:15]1.O=C1C[NH:26][C@H](C(O)=O)C1.NN>>[N:2]1([C:14]2[CH:15]=[CH:16][NH:17][N:26]=2)[CH2:1][CH2:9][CH2:4][CH2:3]1

Komponenten

5

Edukt 4

HCID 9321HydrazineHCID 69248L-Proline, 4-hydroxy-, cis-HCID 1075414-oxo-L-prolineHCID 18541318HCID 18541318, Verbindung

Produkt 1

HCID 178420599HCID 178420599, Verbindung

Versuchsvorschrift

Heteroaryl derivatives to replace 1,3-dihydro-2H-isoindole-1-carboxylate may be prepared as outlined in Scheme 2. 4-Hydroxy-(L)-proline derivative D is oxidized to 4-keto-(L)-proline E which is formylated and then treated with an appropriate hydrazine derivative to form pyrrolidinyl-pyrazole F. The ester in F is hydrolyzed and reacted with amino acid C followed by protecting group removal to form G. The pyrrolidine-amine in G is sulfonylated and the ester removed to form the desired product H.

Aufarbeitung

  1. custommay be prepared

Quellen und Nachweise

ORD-Eintrag
ord-9c0fbb7e03c946b290c7a91e47da18dd
Quelldatensatz
uspto-grants-2003_05
Patentnummer
US06559174B2

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