Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrazine → HCID 178420599, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrazine | HCID 9321 | — |
| 반응물 | L-Proline, 4-hydroxy-, cis- | HCID 69248 | — |
| 반응물 | 4-oxo-L-proline | HCID 107541 | — |
| 반응물 | HCID 18541318 | HCID 18541318 | — |
| 생성물 | HCID 178420599 | HCID 178420599 | — |
반응 단계
Heteroaryl derivatives to replace 1,3-dihydro-2H-isoindole-1-carboxylate may be prepared as outlined in Scheme 2. 4-Hydroxy-(L)-proline derivative D is oxidized to 4-keto-(L)-proline E which is formylated and then treated with an appropriate hydrazine derivative to form pyrrolidinyl-pyrazole F. The ester in F is hydrolyzed and reacted with amino acid C followed by protecting group removal to form G. The pyrrolidine-amine in G is sulfonylated and the ester removed to form the desired product H.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06559174B2 |
| 출처 데이터셋 | uspto-grants-2003_05 |
| ORD ID | ord-9c0fbb7e03c946b290c7a91e47da18dd |
| 출처 메모 | uspto-grants-2003_05 |