Hydrochloric Acid → HCID 69376873, compound

Participants

Reaction Steps

A solution of 99 mg (0.16 mmol) of 5-(BOC)-1-ethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-4(S)-carbonyl)-4-(3 ′,5′-dichloroisonicotinoyl)amino-(L)-phenylalanine, methyl ester in 1 mL of EtOAc was treated with 3 mL of EtOAc saturated with HCl gas. A precipitate was formed immediately. After 1 hr the solid was filtered, washed with EtOAc and dried to yield 1-ethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-4(S)-carbonyl)-4-(3′,5′-dichloroisonicotinoyl)amino-(L)-phenylalanine, methyl ester, hydrochloride (82 mg).

Provenance & Evidence