Hydrochloric Acid → HCID 69376873, compound

HRID 411751Notes

Reaction equation

HRID 411751 reaction equation
[Cl:1][C:2]1[CH:23]=[N:22][CH:21]=[C:20]([Cl:24])[C:3]=1[C:4]([NH:6][C:7]1[CH:19]=[CH:18][C:10]([CH2:11][C@@H:12]([C:14]([O:16][CH3:17])=[O:15])[NH2:13])=[CH:9][CH:8]=1)=[O:5].Cl>CCOC(C)=O>[ClH:1].[Cl:24][C:20]1[CH:21]=[N:22][CH:23]=[C:2]([Cl:1])[C:3]=1[C:4]([NH:6][C:7]1[CH:19]=[CH:18][C:10]([CH2:11][C@@H:12]([C:14]([O:16][CH3:17])=[O:15])[NH2:13])=[CH:9][CH:8]=1)=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58724387HCID 58724387, compound

Product 1

HCID 69376873HCID 69376873, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A solution of 99 mg (0.16 mmol) of 5-(BOC)-1-ethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-4(S)-carbonyl)-4-(3 ′,5′-dichloroisonicotinoyl)amino-(L)-phenylalanine, methyl ester in 1 mL of EtOAc was treated with 3 mL of EtOAc saturated with HCl gas. A precipitate was formed immediately. After 1 hr the solid was filtered, washed with EtOAc and dried to yield 1-ethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-4(S)-carbonyl)-4-(3′,5′-dichloroisonicotinoyl)amino-(L)-phenylalanine, methyl ester, hydrochloride (82 mg).

Workup

  1. customA precipitate was formed immediately
  2. filtrationAfter 1 hr the solid was filtered
  3. washwashed with EtOAc
  4. customdried

Sources & evidence

ORD record
ord-34ebf61a2aac487b8b26d57127818c73
Source dataset
uspto-grants-2003_05
Patent number
US06559174B2

Reaction notes

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