Sulfuric Acid → 5-Chlorohexanoic acid

HRID 411807Notes

Reaction equation

HRID 411807 reaction equation
[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].S(=O)(=O)(O)O.[Cl:14]N(C(C)C)C(C)C>>[Cl:14][CH:5]([CH3:6])[CH2:4][CH2:3][CH2:2][C:1]([OH:8])=[O:7]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 8892Hexanoic AcidHCID 32745N-Chloro-N,N-diisopropylamine

Product 1

HCID 185416685-Chlorohexanoic acid

Procedure

135 parts by mass of the caproic acid were added to 1,000 parts by mass of 84% sulfuric acid and an equivalent amount of N-chlorodiisopropylamine and were reacted for 5 hours at 25° C. to obtain 163 parts by mass of 5-chlorocaproic acid.

Sources & evidence

ORD record
ord-e00c1458200e40adb14489b39ada7486
Source dataset
uspto-grants-2003_05
Patent number
US06559275B2

Reaction notes

Loading…