反应详情

温度

80 °C

A mixture of 3,3-bis-(3-trifluoromethylphenoxy)-acrolein (10 mmoles), 4-trifluoromethylbenzamidine (10 mmoles), potassium carbonate (10 mmoles) and acetonitril (100 ml), is stirred at 80° C. for four hours. The reaction mixture is cooled down to ambient temperature and filtered through silica. The organic phase is washed with ethyl acetate and concentrated in vacuo. The residue is purified by chromatography on Al2O3 (petrol ethers/ethyl acetate: 2/1) to yield 3.06 g (80%) of the pure product having a melting point of 66° C.

1. temperatureThe reaction mixture is cooled down to ambient temperature
2. filtrationfiltered through silica
3. washThe organic phase is washed with ethyl acetate
4. concentrationconcentrated in vacuo
5. customThe residue is purified by chromatography on Al2O3 (petrol ethers/ethyl acetate: 2/1)