反应详情

2,4,6-Triethoxycarbonyl-s-triazine (1 g, 3.36 mmol) is dissolved in dichloromethane (15 mL) and absolute ethanol (25 mL) then cooled to 0° C. before sodium borohydride (127 mg, 3.36 mmol) is added. After 15 minutes calcium chloride (373 mg, 2.97 mmol) is added and the reaction mixture is warmed to room temperature. The reaction mixture is dried to a yellow solid and subjected to soxhlet extraction with ethanol. The ethanol is evaporated to a white solid. The product is crystallized from Methanol and water or purified by silica gel flash column chromatography to give the title compound.

1. additionis added
2. customThe reaction mixture is dried to a yellow solid
3. extractionextraction with ethanol
4. customThe ethanol is evaporated to a white solid
5. customThe product is crystallized from Methanol and water
6. custompurified by silica gel flash column chromatography