Hydrochloric Acid → Benzeneacetic acid, alpha-methyl-, ethyl ester

HRID 411895Notes

Reaction equation

HRID 411895 reaction equation
[C:1]1([CH:7]([CH3:11])[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH2:13](O)[CH3:14]>>[C:1]1([CH:7]([CH3:11])[C:8]([O:10][CH2:13][CH3:14])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702Ethanol2×HCID 102962-Phenylpropionic acid

Product 1

HCID 99643Benzeneacetic acid, alpha-methyl-, ethyl ester

Procedure

Dissolve 2-phenylpropionic acid (30 g) in 2B ethanol (100 mL and add anhydrous HCl (10 g). Allow to sit for 48-72 hours, evaporate the solvent in vacuo and purify by distillation to give ethyl 2-phenylpropionate (31 g); bp 100 C at 6 mmm.

Workup

  1. customevaporate the solvent in vacuo
  2. distillationpurify by distillation

Sources & evidence

ORD record
ord-44239cf2a4464f8c9630966e8820d0f3
Source dataset
uspto-grants-2003_05
Patent number
US06559312B2

Reaction notes

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