Aniline → 6-Nitro-N-phenylquinazolin-4-amine

HRID 411945Notes

Reaction equation

HRID 411945 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([N+:19]([O-:21])=[O:20])[CH:17]=2)[N:12]=[CH:11][N:10]=1>C(O)(C)C>[C:2]1([NH:1][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([N+:19]([O-:21])=[O:20])[CH:17]=3)[N:12]=[CH:11][N:10]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6115Aniline2×HCID 113562574-Chloro-6-nitroquinazoline

Product 1

HCID 53281896-Nitro-N-phenylquinazolin-4-amine

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Aniline or derivatized aniline (1 equivalent) is reacted with 4-chloro-6-nitroquinazoline (3.5 equivalents), in a polar solvent such as iso-propylalcohol. The product, 4-(phenylamino)-6-nitroquinazoline, is obtained after filtration.

Sources & evidence

ORD record
ord-9f799eb6e18641d0b816532f9a5df4f8
Source dataset
uspto-grants-2003_05
Patent number
US06562319B2

Reaction notes

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