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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 411947Generated: October 25, 2026

4,5-Dichloro-2-fluoroaniline → 4-[(3,4-Dichloro-6-fluorophenyl)amino]-6-nitroquinazoline

https://huagongshe.com/reaction/411947

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4,5-Dichloro-2-fluoroanilineHCID 223091—
Reactant4-Chloro-6-nitroquinazolineHCID 11356257—
SolventIsopropanolHCID 3776—
Product4-[(3,4-Dichloro-6-fluorophenyl)amino]-6-nitroquinazolineHCID 15480998—

Reaction Steps

3,4-Dichloro-6-fluoroaniline (1 equivalent) was reacted with 4-chloro-6-nitroquinazoline (3.5 equivalents), in iso-propylalcohol. After filtration, 4-[(3,4-dichloro-6-fluorophenyl)amino]-6-nitroquinazoline (compound 1) was obtained in 78% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06562319B2
Source datasetuspto-grants-2003_05
ORD IDord-4a4f25d577154b809f69c5e6408ff8e5
Source noteuspto-grants-2003_05