Hydrochloric Acid → HCID 136047380, compound

HRID 412027Notes

Reaction equation

HRID 412027 reaction equation
[CH2:1]([O:4][C:5]1[CH:22]=[CH:21][CH:20]=[CH:19][C:6]=1[C:7]([NH:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12]([NH2:14])=[O:13])=O)[CH2:2][CH3:3].[OH-].[Na+].Cl>N1C=CC=CC=1>[CH2:1]([O:4][C:5]1[CH:22]=[CH:21][CH:20]=[CH:19][C:6]=1[C:7]1[NH:14][C:12](=[O:13])[C:11]2[C:10](=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:9]=1)[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 4947826HCID 4947826, compound

Product 1

HCID 136047380HCID 136047380, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-(2-Propoxybenzamido)benzamide (2.73 g) was added to a refluxing mixture of 2 Normal aqueous sodium hydroxide (55 ml) and pyridine (2 ml). The resulting solution was stirred under reflux for 15 minutes and was then poured onto ice (150 ml) and acidified with concentrated hydrochloric acid to yield a sample of the title compound, 2.28 g, m.p. 88-89° C. This together with another sample (0.77 g) similarly prepared was recrystallized from ethanol/water to yield the pure title compound as a white solid, 2.57 g, m.p. 89-90° C.

Workup

  1. temperatureunder reflux for 15 minutes
  2. additionwas then poured onto ice (150 ml)

Sources & evidence

ORD record
ord-9f7a0d7bde114f6a8d5daad818d275d7
Source dataset
uspto-grants-2003_05
Patent number
US06562830B1

Reaction notes

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