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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 412066Generated: November 1, 2026

Piperazine → Ethyl 2-(piperazin-1-yl)nicotinate

https://huagongshe.com/reaction/412066

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperazineHCID 4837—
ReactantEthyl chloronicotinateHCID 2796614—
SolventEthanolHCID 702—
ProductEthyl 2-(piperazin-1-yl)nicotinateHCID 11615598—

Reaction Steps

10.0 g of ethyl 2-chloronicotinate were reacted with 27.8 g of piperazine in 400 ml of ethanol analogously to Example 18a, 6.9 g (54%) of the product being obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06562827B1
Source datasetuspto-grants-2003_05
ORD IDord-acbd33bb3e544888a86f52dde181f243
Source noteuspto-grants-2003_05