Piperazine → ethyl 2-(piperazin-1-yl)nicotinate

HRID 412066Notes

Reaction equation

HRID 412066 reaction equation
Cl[C:2]1[N:12]=[CH:11][CH:10]=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>C(O)C>[N:13]1([C:2]2[N:12]=[CH:11][CH:10]=[CH:9][C:3]=2[C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 2796614Ethyl chloronicotinate

Product 1

HCID 11615598ethyl 2-(piperazin-1-yl)nicotinate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10.0 g of ethyl 2-chloronicotinate were reacted with 27.8 g of piperazine in 400 ml of ethanol analogously to Example 18a, 6.9 g (54%) of the product being obtained.

Workup

  1. custombeing obtained

Sources & evidence

ORD record
ord-acbd33bb3e544888a86f52dde181f243
Source dataset
uspto-grants-2003_05
Patent number
US06562827B1

Reaction notes

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