HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 8-(1-(4-fluorophenyl)pyrrolidin-2-yl)-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | methyl 8-[(2R)-(1-(4-fluorophenyl)pyrrolidin-2-yl)]-2-morpholino-4-oxo-4H-chromene-6-carboxylate | HCID 86672433 | — |
| Product | 8-(1-(4-fluorophenyl)pyrrolidin-2-yl)-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid | HCID 86672434 | 83.3% |
Reaction Steps
Methyl 8-[(2R)-(1-(4-fluorophenyl)pyrrolidin-2-yl)]-2-morpholino-4-oxo-4H-chromene-6-carboxylate (119 mg, 0.26 mmol from 2 different batches) was reacted with sodium hydroxide to give 8-(1-(4-fluorophenyl)pyrrolidin-2-yl)-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid (enantiomer 2, 95 mg, 82%) as a yellow solid. Mass Spectrum: m/z [M+H]+=439.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08530470B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-c1b96ea506cf433fb4fa9c9548d35964 |
| Source note | uspto-grants-2013_09 |