HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-[3-(Hydroxy)benzyl]-2-piperazinone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-[(3-hydroxyphenyl)methyl]-3-oxopiperazine-1-carboxylate | HCID 18536065 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-[3-(Hydroxy)benzyl]-2-piperazinone hydrochloride | HCID 18536072 | — |
Reaction Steps
Through a solution of the product from Step J (68 mg, 0.22 mmol) in 3.0 mL of ethyl acetate at 0° C. was bubbled anhydrous HCl gas for 5 minutes. After 15 minutes, the solution was concentrated in vacuo to provide the titled salt as a white foam which was used in the next reaction without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06562823B1 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-1d48fd66f33844fbbc50e24c398f6982 |
| Source note | uspto-grants-2003_05 |