Hydrochloric Acid → 1-[3-(Hydroxy)benzyl]-2-piperazinone hydrochloride

HRID 412123Notes

Reaction equation

HRID 412123 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:20]=[CH:21][CH:22]=1)[CH2:5][N:6]1[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][C:7]1=[O:19].[ClH:23]>C(OCC)(=O)C>[ClH:23].[OH:1][C:2]1[CH:3]=[C:4]([CH:20]=[CH:21][CH:22]=1)[CH2:5][N:6]1[CH2:11][CH2:10][NH:9][CH2:8][C:7]1=[O:19]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18536065Tert-butyl 4-[(3-hydroxyphenyl)methyl]-3-oxopiperazine-1-carboxylate

Product 1

HCID 185360721-[3-(Hydroxy)benzyl]-2-piperazinone hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Through a solution of the product from Step J (68 mg, 0.22 mmol) in 3.0 mL of ethyl acetate at 0° C. was bubbled anhydrous HCl gas for 5 minutes. After 15 minutes, the solution was concentrated in vacuo to provide the titled salt as a white foam which was used in the next reaction without further purification.

Workup

  1. concentrationthe solution was concentrated in vacuo

Sources & evidence

ORD record
ord-1d48fd66f33844fbbc50e24c398f6982
Source dataset
uspto-grants-2003_05
Patent number
US06562823B1

Reaction notes

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