Trifluoroacetic acid → HCID 18536162, compound

HRID 412181Notes

Reaction equation

HRID 412181 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[C:23]([O:26][S:27]([CH3:30])(=[O:29])=[O:28])[CH:24]=3)[CH:19]=[CH:18][CH:17]=2)=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34]>ClCCl>[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].[CH3:30][S:27]([O:26][C:23]1[CH:24]=[C:25]2[C:20]([CH:19]=[CH:18][CH:17]=[C:16]2[C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[O:15])=[CH:21][CH:22]=1)(=[O:28])=[O:29]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18536042HCID 18536042, compound

Product 1

HCID 18536162HCID 18536162, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the product from Step F (560 mg, 1.20 mmol) in dichloromethane (40 mL) at 0° C. was added trifluoroacetic acid (10 mL). The solution was stirred for 2 hours and then concentrated in vacuo to yield the titled compound.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-2b9a421092f14208b9c866af1034b189
Source dataset
uspto-grants-2003_05
Patent number
US06562823B1

Reaction notes

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