反应详情

A solution of the product from Step A (970 mg, 6.5 mmol) and (carbethoxymethylene)triphenylphosphorane (2.3 g, 6.5 mmol) was heated at reflux in 50 mL of toluene overnight. The reaction was concentrated in vacuo, triturated with ether, and filtered. The filtrate was concentrated in vacuo, and purified by flash column chromatography on silica gel (15% EtOAc/hexane) to yield the desired product as a white solid.

1. concentrationThe reaction was concentrated in vacuo
2. customtriturated with ether
3. filtrationfiltered
4. concentrationThe filtrate was concentrated in vacuo
5. custompurified by flash column chromatography on silica gel (15% EtOAc/hexane)