Water → HCID 86672441, compound

HRID 41223Notes

Reaction equation

HRID 41223 reaction equation
[OH-].[Na+].[CH3:3][C@@H:4]1[CH2:9][N:8]([C:10]2[O:11][C:12]3[C:17]([C:18](=[O:20])[CH:19]=2)=[CH:16][C:15]([C:21]([O:23]C)=[O:22])=[CH:14][C:13]=3[CH:25]2[CH2:29][CH2:28][CH2:27][N:26]2[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH2:7][CH2:6][O:5]1.O>CO>[CH3:3][C@@H:4]1[CH2:9][N:8]([C:10]2[O:11][C:12]3[C:17]([C:18](=[O:20])[CH:19]=2)=[CH:16][C:15]([C:21]([OH:23])=[O:22])=[CH:14][C:13]=3[CH:25]2[CH2:29][CH2:28][CH2:27][N:26]2[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH2:7][CH2:6][O:5]1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 86672442methyl 2-((R)-2-methylmorpholino)-4-oxo-8-(1-phenylpyrrolidin-2-yl)-4H-chromene-6-carboxylate

Product 1

HCID 86672441HCID 86672441, compoundYield 87.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sodium hydroxide (2N in water) (0.293 mL, 0.59 mmol) was added to a stirred suspension of methyl 2-((R)-2-methylmorpholino)-4-oxo-8-(1-phenylpyrrolidin-2-yl)-4H-chromene-6-carboxylate (105 mg, 0.23 mmol) in MeOH (2 mL)/water (2 mL) as described in example 3.00 to afford 2-((R)-2-methylmorpholino)-4-oxo-8-(1-phenylpyrrolidin-2-yl)-4H-chromene-6-carboxylic acid (87 mg, 86%) which was used without further purification. Mass Spectrum: m/z [M+H]+=435.

Sources & evidence

ORD record
ord-caaf9d55659a4e6ebd6917ce3d492a5c
Source dataset
uspto-grants-2013_09
Patent number
US08530470B2

Reaction notes

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