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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 41223Generated: October 28, 2026

Water → HCID 86672441, compound

https://huagongshe.com/reaction/41223

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantSodium HydroxideHCID 14798—
Reactantmethyl 2-((R)-2-methylmorpholino)-4-oxo-8-(1-phenylpyrrolidin-2-yl)-4H-chromene-6-carboxylateHCID 86672442—
SolventMethanolHCID 887—
ProductHCID 86672441HCID 8667244187.1%

Reaction Steps

Sodium hydroxide (2N in water) (0.293 mL, 0.59 mmol) was added to a stirred suspension of methyl 2-((R)-2-methylmorpholino)-4-oxo-8-(1-phenylpyrrolidin-2-yl)-4H-chromene-6-carboxylate (105 mg, 0.23 mmol) in MeOH (2 mL)/water (2 mL) as described in example 3.00 to afford 2-((R)-2-methylmorpholino)-4-oxo-8-(1-phenylpyrrolidin-2-yl)-4H-chromene-6-carboxylic acid (87 mg, 86%) which was used without further purification. Mass Spectrum: m/z [M+H]+=435.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08530470B2
Source datasetuspto-grants-2013_09
ORD IDord-caaf9d55659a4e6ebd6917ce3d492a5c
Source noteuspto-grants-2013_09