反应详情

温度

40 °C

An aqueous NaOH 2N (0.804 ml, 1.61 mmol) solution was added to methyl 8-(1-(3-fluorophenyl)pyrrolidin-2-yl)-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxylate (0.25 g, 0.54 mmol) suspended in MeOH (4 mL). The solution was stirred at 40° C. overnight then cooled to 0° C. and an aqueous HCl 2N (0.670 ml, 1.34 mmol) solution was added dropwise to the reaction mixture until pH ˜3. The resulting precipitate was collected by filtration, washed with water and dried under vacuum at 50° C. in presence of P2O5 to a constant weight to afford 8-(1-(3-fluorophenyl)pyrrolidin-2-yl)-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxylic acid (201 mg, 83%) as a beige solid. Mass Spectrum: m/z [M+H]+=453.

1. temperaturethen cooled to 0° C.
2. filtrationThe resulting precipitate was collected by filtration
3. washwashed with water
4. dry with materialdried under vacuum at 50° C. in presence of P2O5 to a constant weight