Hydrochloric Acid → HCID 136342541, compound

HRID 412291Notes

Reaction equation

HRID 412291 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([C:15]2[C:20]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:19][CH:18]=[CH:17][C:16]=2[OH:29])[CH:5]=[C:6]2[C:13]=1[CH2:12][N:11]1[CH2:14][CH:7]2[CH2:8][CH2:9][CH2:10]1.[ClH:30]>O1CCOCC1>[ClH:30].[NH2:1][C:2]1[N:3]=[C:4]([C:15]2[C:20]([O:21][CH2:22][C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)=[CH:19][CH:18]=[CH:17][C:16]=2[OH:29])[CH:5]=[C:6]2[C:13]=1[CH2:12][N:11]1[CH2:14][CH:7]2[CH2:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136050675HCID 136050675, compound

Product 1

HCID 136342541HCID 136342541, compoundYield 19%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a stirred solution of 2-(6-amino-5,9-diazatricyclo[7.3.1.02,7]trideca-2,4,6-trien-4-yl)-3-(benzyloxy)phenol in 1,4-dioxane (2 mL) was added 4N HCl in dioxane (2 mL). The mixture was stirred at room temperature for 2 hrs. The resulted precipitate was collected by filtration, washed with acetonitril, and dried under reduced pressure to give 2-(6-amino-5,9-diazatricyclo[7.3.1.02,7]trideca-2,4,6-trien-4-yl)-3-(benzyloxy)phenol hydrochloride.(0.018 g, yield 19%).

Workup

  1. filtrationThe resulted precipitate was collected by filtration
  2. washwashed with acetonitril
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-114a22ff81fa47c2a6e6daad31a036cb
Source dataset
uspto-grants-2003_05
Patent number
US06562811B1

Reaction notes

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