Methanol → HCID 54109341, compound

Temperature

2.5 °C

Under a nitrogen environment, 109 g of n-propyltriphenylphosphonium bromide was suspended in 200 ml of tetrahydrofuran and 31.6 g of potassium-t-butoxide was added thereto over 5 minutes at 0° C. The mixture was then stirred at 0 to 5° C. for 1 hour. To the mixture, there was eye-dropped at 0 to 5° C. over 30 minutes, a solution in which 40.0 g of methyl 2,2-dimethyl-3-formylcyclopropanecarboxylate, as produced in Reference Example 1 above, was dissolved in 40 ml of tetrahydrofuran. The resulting reaction mixture was then stirred for 3 hours at 0 to 5° C. Subsequently, 24.6 g of an aqueous 50% sodium hydroxide solution and 40 ml of methanol were added to the reaction mixture. The resulting reaction mixture was stirred for 3 hours at 60° C. After the reaction mixture was allowed to cool to room temperature, 150 ml of toluene and 100 ml of ice water were then poured into the reaction mixture to separate the reaction mixture into an aqueous layer and an organic layer. After the aqueous layer was extracted therefrom, 100 ml of a 20% hydrochloric acid solution was added the aqueous layer. The resulting aqueous layer was then extracted twice with 300 ml of toluene. After the organic layers therefrom were combined, the resulting mixture was dried with anhydrous magnesium sulfate and concentrated under reduced pressure to provide 35 g of 2,2-dimethyl-3-(1-butenyl)cyclopropanecarboxylic acid. In the isolated 2,2-dimethyl-3-(1-butenyl)cyclopropanecarboxylic acid, the molar ratio of the (Z) isomer thereof at the 1-butenyl group to the (E) isomer thereof at the 1-butenyl group was 8:1.

1. customThe resulting reaction mixture
2. customThe resulting reaction mixture
3. stirringwas stirred for 3 hours at 60° C
4. temperatureto cool to room temperature
5. customto separate the reaction mixture into an aqueous layer
6. extractionAfter the aqueous layer was extracted
7. addition100 ml of a 20% hydrochloric acid solution was added the aqueous layer
8. extractionThe resulting aqueous layer was then extracted twice with 300 ml of toluene
9. dry with materialthe resulting mixture was dried with anhydrous magnesium sulfate
10. concentrationconcentrated under reduced pressure

ORD record

ord-820ac7d58a9b40dfa9a1944cf77bbf80

Source dataset

uspto-grants-2003_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06562853B2