反应详情

A mixture of 5-[4-[6-(4-n-hexylaminophenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl]thiazolidine-2,4-dione (0.39 g), phenyl isocyanate (95 mg) and anhydrous tetrahydrofuran (20 ml) was allowed to stand at room temperature for 2 days. The reaction mixture was concentrated and partitioned between ethyl acetate and water. The extract was dried over anhydrous sodium sulfate and then concentrated. The residue was chromatographed on a silica gel column using ethyl acetate:n-hexane=3:2 as the eluant and the product was reprecipitated from a mixture of n-hexane and diethyl ether to afford the title compound (0.30 g, Rf=0.56: thin layer chromatography on a silica gel plate using ethyl acetate:n-hexane=2:1 as the eluant).

1. concentrationThe reaction mixture was concentrated
2. custompartitioned between ethyl acetate and water
3. dry with materialThe extract was dried over anhydrous sodium sulfate
4. concentrationconcentrated
5. customThe residue was chromatographed on a silica gel column
6. customn-hexane=3:2 as the eluant and the product was reprecipitated from a mixture of n-hexane and diethyl ether